Vitamin B6 (Pyridoxine) for Nausea Relief

Research suggests that vitamin B6 (pyridoxine) may help reduce nausea and vomiting, particularly in the context of pregnancy, with supporting evidence drawn from randomized controlled trials and a broader review of clinical literature. Studies indicate that pyridoxine performed comparably to ginger in one head-to-head trial among pregnant women, and a 1998 review of ten randomized trials found some evidence of benefit for pyridoxine alongside other non-pharmaceutical approaches. One randomized controlled trial also found that a combination product containing pyridoxine and doxylamine reduced postoperative vomiting in a later recovery window, though it showed no significant effect in the first six hours after surgery. Overall, the evidence is generally supportive but limited in scope, with researchers consistently calling for larger and more rigorous studies, and much of the existing work focuses on pregnancy-related nausea rather than nausea from other causes.