Vitamin B6 is a water-soluble vitamin that plays a central role in over 100 enzymatic reactions in the body, particularly those involving amino acid metabolism, neurotransmitter synthesis, and immune function. Research suggests that adequate B6 intake supports cognitive health and mood regulation, likely through its involvement in producing serotonin, dopamine, and GABA. Studies indicate that B6, often in combination with folate and B12, may help reduce elevated homocysteine levels, a marker associated with cardiovascular risk. There is also a well-established body of evidence supporting its use for pregnancy-related nausea, and some research points to benefits for premenstrual symptoms. The active coenzyme form, pyridoxal-5-phosphate (P5P), is the form directly utilized by the body, which has drawn interest for its potential advantages in absorption and bioavailability compared to standard pyridoxine hydrochloride.
Compare this supplementResearch suggests that vitamin B6 may offer modest support for mood-related outcomes in specific populations, with th...
View studies →Research suggests that vitamin B6 (pyridoxine) may help reduce nausea and vomiting, particularly in the context of pr...
View studies →Research suggests that the evidence for vitamin B6 supplementation improving cognitive function in older adults is li...
View studies →Research suggests a limited and indirect connection between vitamin B6 and immune function in the studies provided, a...
View studies →Research suggests that the available study linked here does not directly investigate Vitamin B6 or its relationship t...
View studies →Research suggests that the available published evidence directly examining Vitamin B6 for pain relief is extremely li...
View studies →Research suggests that vitamin B6, when combined with other ingredients such as Vitex agnus-castus extract and magnes...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 20–40 mg | Daily | Mood support and cognitive function | Used in RCTs examining B6 effects on serotonin synthesis and cognitive performance in older adults |
| Tablet | 100–200 mg | Daily | Carpal tunnel syndrome and neuropathic pain relief | Used in clinical studies for peripheral nerve-related pain; long-term high doses carry neuropathy risk |
| Tablet | 1.3–2 mg | Daily | General health and immune function (meeting RDA for adults) | Based on established dietary reference intakes and general supplementation trials |
| Tablet | 25–100 mg | Daily | Homocysteine reduction and cardiovascular support | Common in RCTs studying B-vitamin combinations for homocysteine lowering |
| Tablet | 10–25 mg | Three times daily | Nausea relief during pregnancy (morning sickness) | Supported by RCTs; FDA-approved combination (Diclegis) uses 10 mg per dose |
| Tablet | 50–100 mg | Daily | PMS relief including mood symptoms and bloating | Common dose in clinical trials for premenstrual syndrome |