Cat's Claw (Una De Gato) for Anti-Inflammatory

Research suggests that cat's claw (Uncaria tomentosa) possesses anti-inflammatory properties, with mechanistic studies pointing to inhibition of NF-κB signaling and suppression of TNF-alpha as likely key pathways, and animal studies showing reductions in markers of intestinal inflammation. The available evidence comes primarily from laboratory cell studies, animal models, and narrative reviews rather than randomized controlled trials or large-scale human outcome studies, which limits how confidently findings can be applied to human health. Studies indicate that while the plant's traditional use for inflammatory conditions such as osteoarthritis and rheumatoid arthritis is consistent with its observed molecular activity, clinical evidence remains preliminary and preparations are not well standardized across studies. One review characterized the overall clinical picture as inconclusive, and researchers across multiple papers consistently note that further rigorous human trials are needed before stronger conclusions can be drawn.