Karela, commonly known as bitter gourd or bitter melon (Momordica charantia), has a long history of use in traditional medicine systems across Asia, Africa, and Latin America. Research suggests that bioactive compounds in bitter gourd, including charantin, polypeptide-p, and vicine, may support healthy blood sugar metabolism by influencing glucose uptake and insulin signaling pathways. Studies indicate that bitter gourd extracts may also contribute to liver health by promoting antioxidant enzyme activity and supporting the body's natural detoxification processes. Additionally, preliminary research has explored its potential role in skin health, possibly linked to its rich content of vitamins A and C along with various anti-inflammatory compounds. Bitter gourd is most commonly consumed as a fresh juice or taken as a standardized extract in supplement form.
Compare this supplementResearch suggests that bitter gourd (Momordica charantia) shows meaningful promise for supporting blood sugar regulat...
View studies →Research suggests that bitter gourd (karela) may support liver health by reducing fat accumulation, lowering oxidativ...
View studies →Research suggests that bitter melon (Momordica charantia) may offer some benefits for skin health, primarily through ...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 500–1,000 mg | Twice daily | Blood sugar regulation in type 2 diabetes | Common in clinical trials examining glycemic control |
| Capsule | 500–1,000 mg | Daily | Liver health and antioxidant support | Based on preclinical and limited clinical research on hepatoprotective effects |
| Extract | 100–200 mg | Three times daily | Blood sugar regulation | Standardized extract doses used in clinical studies |
| Liquid | 50–100 ml | Daily | Blood sugar regulation and liver health | Traditional use as fresh juice; referenced in ethnobotanical and clinical literature |
| Powder | 2–6 g | Daily | Blood sugar regulation and general metabolic health | Based on RCTs using dried bitter gourd powder |
| Topical | — | As needed | Skin health and wound healing | Traditional use; limited clinical evidence; concentration not well standardized |