He Shou Wu (Fo-Ti) for Hair Health

Research suggests that He Shou Wu (Polygonum multiflorum) has a traditional history of use for hair blackening and anti-aging, and preclinical studies indicate that its primary bioactive compound, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), may promote hair regrowth through mechanisms including reduced oxidative stress, improved mitochondrial function, and enhanced telomerase activity. The available evidence comes primarily from reviews and systematic reviews of preclinical research rather than from human clinical trials, meaning these findings have not yet been reliably confirmed in controlled studies with human participants. Studies indicate that while the plant contains over 175 identified bioactive compounds with a range of reported biological activities, the evidence base remains largely preliminary, and standardized methods for evaluating efficacy are still lacking. Importantly, all three reviews flag hepatotoxicity as a significant and well-documented safety concern associated with Polygonum multiflorum use, with liver injury reports documented across multiple countries, underscoring that any interest in this herb should be considered alongside its potential risks.