Coleus Forskohlii (Forskolin) for Eye Health

Research suggests that forskolin may support eye health, particularly in the context of glaucoma, by lowering intraocular pressure through activation of cyclic AMP signaling pathways in the eye. The available evidence base, however, is limited to a single 2024 narrative review that synthesized preclinical and clinical findings on forskolin alongside a green tea compound called EGCG, and no independent randomized controlled trials or meta-analyses are represented in this summary. Studies indicate that the direction of findings is generally supportive, with researchers proposing forskolin as a potential adjunctive approach to managing retinal conditions such as glaucoma and age-related macular degeneration, though the authors themselves acknowledged the need for further research, including investigation into whether combining these compounds produces meaningful synergistic effects. Given the limited and preliminary nature of the current evidence, these findings should be interpreted cautiously, and the research is far from sufficient to draw firm conclusions about efficacy or clinical utility.