Ergothioneine is a naturally occurring amino acid produced by certain fungi, bacteria, and soil organisms, with particularly rich concentrations found in mushrooms like shiitake, king oyster, and maitake. Unlike many antioxidants, the human body has a dedicated transporter protein (OCTN1) that actively accumulates ergothioneine in tissues subject to high oxidative stress, including the brain, eyes, liver, and skin, suggesting it plays an important biological role. Research suggests that ergothioneine may help protect cells from oxidative damage and inflammation, with studies indicating potential benefits for cognitive health, neuroprotection, and skin resilience against environmental stressors. Observational research has also linked higher blood levels of ergothioneine with reduced risk of age-related cognitive decline, prompting growing scientific interest in its role as a longevity-associated compound, though more clinical trials are needed to fully understand its effects.
Compare this supplementResearch suggests that ergothioneine may support healthy aging through multiple biological mechanisms, with a growing...
View studies →Research suggests that ergothioneine holds meaningful promise as a neuroprotective compound, with a broadly supportiv...
View studies →Research suggests that ergothioneine may support cognitive function and help protect against age-related neurodegener...
View studies →Research suggests that ergothioneine plays a role in antioxidant defense systems, with available studies examining it...
View studies →Research suggests that ergothioneine, when used as part of a multi-ingredient topical skincare formulation, may suppo...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 10 mg | Daily | cognitive function and neuroprotection | Used in clinical studies examining cognitive outcomes in older adults |
| Capsule | 5 mg | Daily | general antioxidant support and anti-aging | Common dose in early human safety and pharmacokinetic trials |
| Capsule | 25–30 mg | Daily | neuroprotection and oxidative stress reduction | Higher-dose range explored in human intervention trials |
| Topical | 0.5–5 % | Daily | skin health, photoprotection, and anti-aging | Concentration range used in cosmetic and dermatological research |