St. John's Wort may reduce CoQ10 levels by inducing CYP enzymes that metabolize it.
St. John's Wort is a potent CYP3A4 inducer, which may increase the metabolism and clearance of CoQ10.
Consider increasing CoQ10 dose or separating intake if taking St. John's Wort.
Known drug category interactions for these supplements. Especially relevant if you take prescription medications.
Combining St. John's Wort with SSRIs can cause serotonin syndrome, a potentially life-threatening condition.
NEVER combine St. John's Wort with SSRIs, SNRIs, or MAOIs. Wait at least 2 weeks after stopping an SSRI before starting St. John's Wort.
St. John's Wort reduces the effectiveness of hormonal birth control, potentially causing contraceptive failure.
Use a non-hormonal backup contraceptive method while taking St. John's Wort and for one month after stopping.
St. John's Wort significantly reduces warfarin blood levels, potentially causing blood clots.
Do not take St. John's Wort while on warfarin. If already taking both, do not stop St. John's Wort abruptly — consult your doctor.
Statins deplete CoQ10 levels. CoQ10 supplementation may help with statin-related muscle pain.
CoQ10 supplementation is often recommended alongside statins. This is a beneficial interaction, not a harmful one.