Research suggests that zinc plays a meaningful role in wound healing, supported primarily by narrative reviews and preclinical studies rather than large randomized controlled trials. Several reviews consistently highlight zinc's involvement in multiple stages of wound repair, including inflammation, cell proliferation, collagen synthesis, and tissue remodeling, with zinc deficiency clearly linked to impaired healing outcomes. However, the evidence is more mixed regarding the clinical benefit of zinc supplementation in individuals who are not already deficient, and researchers have not reached consensus on optimal supplementation methods or dosing strategies. Topical zinc applications appear to show more consistent promise than oral supplementation for wound care, though the overall body of evidence remains limited by a reliance on reviews, animal models, and observational data, with a need for more rigorous clinical trials to confirm practical benefits in diverse patient populations.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Zinc in Wound Healing Modulation. | Review | 2017 | Supports | 100 |
| Zinc in wound healing: theoretical, experimental, and clinical aspects. | Review | 2007 | Supports | 95 |
| The role of nutrition in wound healing and implications for nursing practice. | Review | 2025 | Mixed | 90 |
| HHIP’s Dynamic Role in Epithelial Wound Healing Reveals a Potential Mechanism... | Other | 2024 | Neutral | 85 |
| Sustained release of magnesium and zinc ions synergistically accelerates woun... | Other | 2023 | Supports | 85 |
| Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells | Other | 2025 | Neutral | 80 |
| Zinc and Skin Disorders. | Review | 2018 | Supports | 80 |
| Rapamycin exerts its geroprotective effects in the ageing human immune system... | Other | 2025 | Neutral | 75 |
| [Nutrition in the prevention and healing of chronic wounds. Importance in imp... | Other | 2021 | Mixed | 75 |
| Hydroxychloroquine and Zinc ameliorate interleukin-6 associated hepato-renal ... | Other | 2023 | Neutral | 70 |
| Zinc: an essential micronutrient. | Other | 2009 | Mixed | 70 |
| Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells | Other | 2025 | Neutral | 65 |
| Zinc. | Review | 1999 | Supports | 65 |
| The brittle star genome illuminates the genetic basis of animal appendage reg... | Other | 2023 | Neutral | 60 |
| Zinc and Wound Healing: A Review of Zinc Physiology and Clinical Applications. | Review | 2017 | Mixed | 60 |
| Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids ... | Other | 2024 | Neutral | 55 |
| Antimicrobial Nano-Zinc Oxide Biocomposites for Wound Healing Applications: A... | Review | 2023 | Supports | 55 |
| Collective border cell migration requires the zinc transporter Catsup to limi... | Other | 2021 | Supports | 50 |
| Nanomaterials for Wound Healing and Infection Control. | Review | 2019 | Supports | 50 |
| Quantitative proteomics reveals differential extracellular vesicle cargo from... | Other | 2024 | Neutral | 45 |
| Canine zinc-responsive dermatosis. | Review | 1999 | Mixed | 45 |
| Clonal memory of colitis accumulates and promotes tumor growth | Other | 2025 | Neutral | 40 |
| Anti-bacterial and wound healing-promoting effects of zinc ferrite nanopartic... | Other | 2021 | Supports | 40 |
| Deciphering the heterogeneity of differentiating hPSC-derived corneal limbal ... | Other | 2023 | Neutral | 35 |
| The Effect of Zinc on Post-neurosurgical Wound Healing: A Review. | Review | 2020 | Supports | 35 |
| Regulatory mechanisms in multiple vascular diseases locus<i>LRP1</i>involve r... | Other | 2023 | Neutral | 30 |
| Zinc and Zinc Transporters in Dermatology. | Review | 2022 | Supports | 30 |
| Giant African snail genomes provide insights into molluscan whole-genome dupl... | Other | 2020 | Neutral | 25 |
| ZEB1 insufficiency causes corneal endothelial cell state transition and alter... | Other | 2019 | Neutral | 20 |
| The activator domain of bacterial collagenases drives collagen recognition, u... | Other | 2023 | Neutral | 15 |