Vitamin B5 (Pantothenic Acid) for Hormonal Balance

Research suggests that the available published evidence linking vitamin B5 (pantothenic acid) specifically to hormonal balance is limited and indirect. The three studies reviewed — a randomized controlled trial, a narrative review, and an animal study — examined pantothenic acid primarily as one component within multi-ingredient formulations or in the context of inflammation and appetite regulation, rather than investigating its effects on hormonal balance as a direct outcome. The randomized trial found no clinically meaningful changes in thyroid hormones when participants consumed a B vitamin-containing hydration drink over four weeks, while the review noted pantothenic acid as a minor constituent of ginseng alongside compounds that may influence appetite-regulating neuropeptides, and the animal study focused on dexpanthenol's anti-inflammatory properties in eye tissue with no hormonal measures assessed. Overall, the current body of evidence does not provide direct or robust support for vitamin B5 as a driver of hormonal balance, and meaningful conclusions in this area would require dedicated clinical research with hormonal outcomes as primary endpoints.