Research suggests that Tribulus terrestris may support sexual function and libido in both men and women, with the bulk of available evidence coming from small randomized controlled trials and narrative reviews that generally point in a positive direction. Studies indicate improvements in desire, arousal, and satisfaction in women with low sexual desire, including those who are premenopausal or postmenopausal, and some trials in men with mild to moderate erectile dysfunction have reported meaningful gains on validated sexual function questionnaires. However, the evidence is not uniformly positive — at least one placebo-controlled trial in men found no statistically significant benefit over placebo at the dose and duration tested — and a key 2016 review challenged the widely held assumption that any effects are driven by raising testosterone, instead pointing to nitric oxide pathways as a more plausible mechanism that has yet to be well studied in humans. Across the literature, sample sizes tend to be small, study durations short, and several trials examined Tribulus terrestris in combination with other herbal ingredients rather than in isolation, all of which makes it difficult to draw firm conclusions about how reliably it works or precisely how it acts.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Evaluation of the efficacy and safety of Tribulus terrestris in male sexual d... | RCT | 2017 | Supports | 72 |
| Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or ... | Review | 2016 | Mixed | 67 |
| Tribulus terrestris and female reproductive system health: A comprehensive re... | Review | 2021 | Supports | 62 |
| Puncture vine (Tribulus Terrestris L.) in control of health and reproduction. | Review | 2021 | Supports | 57 |
| Tribulus terrestris for treatment of sexual dysfunction in women: randomized ... | RCT | 2014 | Supports | 52 |
| Efficacy of Tribulus Terrestris for the treatment of premenopausal women with... | RCT | 2018 | Supports | 47 |
| Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire... | RCT | 2016 | Supports | 42 |
| Effect of a multi-ingredient based food supplement on sexual function in wome... | Other | 2019 | Supports | 37 |
| Recent studies on aphrodisiac herbs for the management of male sexual dysfunc... | Review | 2011 | Supports | 32 |
| Sexual asthenia: Tradamixina versus Tadalafil 5 mg daily. | RCT | 2012 | Supports | 27 |
| Effects of herbal preparation on libido and semen quality in boars. | RCT | 2011 | Supports | 22 |
| Tribulus terrestris versus placebo in the treatment of erectile dysfunction: ... | RCT | 2014 | — | 17 |