Tongkat Ali (Eurycoma Longifolia) for Mood Support

Research suggests that Tongkat Ali may offer modest mood-related benefits in certain populations, though the evidence is mixed and the findings are not consistent across studies. The most relevant clinical trials are randomized, double-blind, placebo-controlled studies focused primarily on menopausal women and stressed adults, with mood assessed as a secondary outcome using validated tools like the Profile of Mood States; in these trials, mood improvements in the Tongkat Ali groups generally trended in a positive direction but often failed to reach statistical significance when compared directly to placebo. One 12-week trial in women experiencing menopausal symptoms found a notable reduction in overall symptom burden at the higher dose studied, with mood disturbance also declining, though the mood difference versus placebo was not statistically significant, and a 24-week trial in moderately stressed adults found meaningful within-group improvements in emotional well-being and vitality but no clear between-group advantage overall. Several of the included studies examined outcomes unrelated to mood entirely, and one multi-ingredient supplement trial reported favorable mood-adjacent findings that cannot be attributed to Tongkat Ali alone, so readers should weigh these results cautiously given the generally modest sample sizes, secondary-outcome status of mood measures, and the mixed picture the body of evidence presents.