Shiitake mushroom (Lentinula edodes) has a long history of use in traditional Asian medicine and cuisine, and modern research has begun exploring several of its bioactive compounds. Studies indicate that lentinan, a polysaccharide found in shiitake, may support immune function by promoting the activity of certain immune cells, while AHCC (Active Hexose Correlated Compound), a fermented extract, has been investigated for its potential role in immune modulation. Research suggests that regular consumption of shiitake may contribute to favorable changes in cholesterol levels and offer antimicrobial properties, though findings are still evolving. Some preliminary studies have also explored its benefits for skin health, including support for conditions related to inflammation, making it an area of growing scientific interest.
Compare this supplementResearch suggests that shiitake mushroom extracts possess notable antimicrobial properties, with laboratory studies d...
View studies →Research suggests that shiitake mushroom contains bioactive compounds — particularly the polysaccharide lentinan, eri...
View studies →Research on shiitake mushroom specifically for cholesterol management is not represented in the currently linked stud...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Extract | 500–1,000 mg | Daily | Antimicrobial properties and immune support | Based on clinical and in vitro research on polysaccharide-rich extracts |
| Extract | 1,600 mg | Daily | Cholesterol management | Used in clinical trials examining lipid-lowering effects of shiitake-derived lentinan |
| Powder | 1.44 g | Daily | Immune function and general health | Used in RCTs examining immune modulation and cytokine response |
| Powder | 5–10 g | Daily | Immune function and general health | Common range used in studies assessing daily whole mushroom powder consumption |
| Topical | — | As needed | Skin health and anti-aging | Applied in cosmetic formulations; standardized dosing not well established in clinical trials |