Shankhpushpi for Neuroprotection

Insufficient evidence 2 studies

Research suggests that Shankhpushpi — a name applied to several distinct plants in Ayurvedic tradition — shows promising neuroprotective properties in preclinical studies, though the evidence base currently consists entirely of animal and cell-based models with no human clinical trials. A 2019 comparative study using cell cultures and scopolamine-treated rats found that methanol extracts from four plants sharing the Shankhpushpi designation all demonstrated neuroprotective activity, with Evolvulus alsinoides performing most consistently across measures including protection against beta-amyloid toxicity, acetylcholinesterase inhibition, and memory preservation. A 2024 study identified a specific mechanism for Convolvulus pluricaulis, finding that its alkaloid Convolamine acts as a positive modulator of the sigma-1 receptor in zebrafish and mouse models, improving cognition under several impairment conditions at low doses. While the directional findings across both studies are supportive, the absence of human trials, the botanical inconsistency inherent in the Shankhpushpi designation, and the early-stage nature of the mechanistic research mean that conclusions about neuroprotective effects in humans cannot yet be drawn.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Neuropharmacological evaluation on four traditional herbs used as nervine ton... Other 2019 Supports 100
Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a ... Other 2024 Supports 95

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