Pqq (Pyrroloquinoline Quinone) for Mitochondrial Function

Research suggests that PQQ may play a role in supporting mitochondrial function, though the current evidence base is limited and largely indirect. The most directly relevant human health study — a preclinical laboratory and animal investigation — found that PQQ restored mitophagy, the cellular process by which damaged mitochondria are identified and cleared, in mesenchymal stem cells derived from obese donors, and that this restoration improved the cells' ability to transfer healthy mitochondria to damaged tissue and reduce inflammatory disease symptoms in mice. The remaining studies in this collection examine PQQ's role in plant immune activation and bacterial ecology, which do not speak to human mitochondrial function. Overall, while the mechanistic findings in cell and animal models are of scientific interest, no randomized controlled trials or human clinical studies are represented here, meaning conclusions about PQQ's effects on mitochondrial function in people cannot yet be drawn from this body of evidence.