Methylsulfonylmethane (MSM) is a naturally occurring organosulfur compound found in small amounts in certain foods and widely used as a dietary supplement to support joint comfort and overall connective tissue health. Research suggests that MSM may help reduce inflammation and oxidative stress, with studies indicating potential benefits for joint pain associated with osteoarthritis, exercise-induced muscle soreness, and post-workout recovery. Some preliminary research also points to improvements in skin health, including support for collagen production and reduced signs of aging, while other studies have explored its role in seasonal allergy relief by helping to moderate histamine-related responses. MSM is generally well-tolerated, with OptiMSM being among the most widely studied and purified forms available, though individual experiences may vary.
Compare this supplementResearch suggests that MSM shows consistent promise for reducing joint pain and improving function in osteoarthritis,...
View studies →Research suggests that MSM may offer some benefit for allergy relief, particularly in the context of allergic rhiniti...
View studies →Research suggests that MSM may support exercise recovery through antioxidant and anti-inflammatory mechanisms, with s...
View studies →Research suggests that MSM may offer benefits for skin health, including potential improvements in skin appearance, h...
View studies →Research suggests that MSM may have anti-inflammatory properties, with at least one 2024 computational and laboratory...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 2,600–3,200 mg | Daily | Allergy relief and seasonal allergic rhinitis | Based on RCTs studying MSM for allergic symptoms over 30-day periods |
| Capsule | 3,000–6,000 mg | Daily | Anti-inflammatory and exercise recovery | Used in clinical trials examining exercise-induced muscle damage and oxidative stress |
| Capsule | 1,500–3,000 mg | Daily | Joint pain relief and osteoarthritis | Common in RCTs studying knee osteoarthritis, often split into 2-3 doses |
| Powder | 3,000–6,000 mg | Daily | General anti-inflammatory and joint support | Common in clinical trials; powder form often used for higher dose protocols |
| Topical | 15 mg | Daily | Skin health, rosacea, and skin aging | Used in topical gel/cream formulations in dermatological studies |