Maitake (Grifola frondosa) is an edible mushroom with a long history of use in traditional Asian herbalism, now gaining attention in modern research for its broad range of potential health benefits. Studies indicate that its beta-glucan compounds, particularly the proprietary Maitake D-fraction extract, may support immune function by enhancing the activity of certain immune cells, with preliminary research exploring its role as a complementary approach in cancer care. Research also suggests that maitake extracts may help support healthy blood sugar levels and insulin sensitivity, which has drawn interest in the context of metabolic health and weight management. Early studies have additionally pointed to possible benefits for blood pressure regulation, though more large-scale human trials are needed to confirm these findings across all areas of investigation.
Compare this supplementThese are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Extract | 0.1–1 mg/kg | Daily | cancer risk reduction and immune modulation | D-fraction dosing used in oncology-supportive clinical research; weight-based dosing from published trials |
| Extract | 500–1,000 mg | Daily | immune function and general health | Common in clinical trials using standardized Maitake D-fraction or whole extract |
| Extract | 100–300 mg | Three times daily | weight management and metabolic health | Based on trials examining appetite and fat metabolism with standardized Maitake extract |
| Powder | 1–3 g | Daily | blood sugar regulation and metabolic support | Used in studies examining glycemic response and insulin sensitivity |
| Tablet | 500–2,000 mg | Daily | blood pressure regulation and cardiovascular support | Ranges observed in studies examining beta-glucan-rich Maitake preparations |