Research suggests that maca root may offer some benefits relevant to menopause, including preliminary animal evidence of bone-protective effects under estrogen-deficient conditions and limited clinical signals around sexual function, but the overall body of evidence remains inconclusive. The available studies include one animal study on bone density, a small systematic review of four randomized controlled trials on sexual function, and two broader reviews of the literature, with findings that are mixed in direction and consistently limited by small sample sizes and weak study designs. Studies indicate that product quality is also a concern, as rapid commercialization may be altering maca's chemical composition in ways that complicate interpretation of research findings. Additionally, one laboratory study raised preliminary safety questions, finding that maca extract at lower concentrations appeared to promote migration and invasiveness in breast cancer cells, which researchers note warrants further investigation particularly for individuals at elevated breast cancer risk, though this research was conducted in cells and cannot be directly applied to human use.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Maca Root (Lepidium meyenii) Extract Increases the Expression of MMP-1 and St... | Other | 2022 | — | 72 |
| Is the hype around the reproductive health claims of maca (Lepidium meyenii W... | Review | 2018 | Mixed | 67 |
| Maca (L. meyenii) for improving sexual function: a systematic review. | Systematic review | 2010 | Mixed | 62 |
| Effect of ethanol extract of Lepidium meyenii Walp. on osteoporosis in ovarie... | Other | 2006 | Supports | 57 |