Lion's Mane Mushroom for Immune Function

Research suggests that fungal supplements may support certain markers related to immune and physiological function in athletes, though the available evidence for Lion's Mane specifically is absent from the current literature base. The one systematic review and meta-analysis identified examined Cordyceps and Ganoderma (reishi) species across 14 randomized controlled trials involving 528 athletes, finding that Ganoderma supplementation was associated with reductions in metabolic stress markers and increases in antioxidant enzyme activity, which may have indirect relevance to immune resilience under physical stress. Studies indicate these effects were most pronounced in endurance athletes, and the overall direction of the evidence leans moderately positive for fungal supplements as a category. However, readers should note that none of the studies in this review examined Lion's Mane directly, meaning conclusions about its immune-related effects cannot be drawn from this body of evidence, and more species-specific research is needed before firm conclusions can be reached.