L-Citrulline for Libido And Sexual Function

Research suggests that L-citrulline may support erectile function and sexual health primarily through its role as a precursor to L-arginine, which the body uses to produce nitric oxide — a molecule essential for the vascular dilation that enables penile erections. The available evidence comes from narrative reviews rather than direct randomized controlled trials on L-citrulline and sexual function specifically, with the supporting literature largely drawing on its established role in nitric oxide metabolism and the well-documented connection between vascular health and erectile function. One review also identified L-citrulline as a candidate worth investigating for sexual performance anxiety, though the authors noted that controlled clinical evidence for this application is currently lacking. Overall, the research directionally supports a plausible mechanism for L-citrulline's relevance to sexual health, but the evidence base consists primarily of reviews and mechanistic reasoning rather than robust clinical trials, meaning conclusions should be interpreted with appropriate caution.