L-Arginine is a semi-essential amino acid that serves as a precursor to nitric oxide, a molecule involved in relaxing and widening blood vessels. Research suggests that L-arginine supplementation may support healthy blood circulation and help maintain blood pressure levels already within a normal range, with several clinical studies pointing to modest improvements in vascular function. Studies also indicate potential benefits for exercise performance, as increased nitric oxide production may enhance blood flow to working muscles, and some research has explored its role in supporting sexual function and wound healing through similar circulatory mechanisms. Available in forms such as free-base L-arginine and L-arginine alpha-ketoglutarate (AAKG), it remains one of the more widely studied amino acids in cardiovascular and sports nutrition research.
Compare this supplementResearch suggests that L-arginine may play a meaningful role in blood pressure regulation, primarily through its func...
View studies →Research suggests that L-arginine supplementation has limited direct evidence for improving exercise performance in h...
View studies →Research suggests that L-arginine plays a meaningful role in blood circulation primarily through its function as a pr...
View studies →Research suggests that L-arginine plays a meaningful role in wound healing, primarily through its function as the pre...
View studies →Research suggests that L-arginine is among the supplements that some men with erectile dysfunction turn to as part of...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 1,500–3,000 mg | Three times daily | Blood pressure regulation | Divided dosing protocol common in hypertension-focused RCTs |
| Powder | 3–6 g | Daily | Blood pressure regulation and cardiovascular health | Common in RCTs examining endothelial function and nitric oxide production |
| Powder | 6–10 g | Daily | Exercise performance and blood circulation | Frequently used in clinical trials assessing exercise capacity and muscle blood flow |
| Powder | 5–9 g | Daily | Libido and sexual function, including erectile dysfunction | Used in clinical studies on male sexual health, often combined with other compounds |
| Powder | 15–30 g | Daily | Wound healing and surgical recovery | Higher doses studied in clinical settings for tissue repair and immune support |