Humic Acid for Anti-Inflammatory

Preliminary evidence 16 studies

Research suggests that humic acid and related humic substances demonstrate notable anti-inflammatory properties across a range of experimental contexts, including models of periodontal disease, spinal cord injury, kidney damage, inflammatory bowel disease, wound healing, and skin conditions such as atopic dermatitis and psoriasis. Studies indicate that proposed mechanisms include suppression of pro-inflammatory cytokines such as TNF-alpha and IL-1 beta, inhibition of NF-κB signaling pathways, scavenging of reactive oxygen and nitrogen species, and modulation of macrophage activity toward tissue-repair-associated states. The available evidence base consists almost entirely of animal studies and laboratory cell culture experiments, with no published human clinical trials directly evaluating humic acid's anti-inflammatory effects, and a 2025 review notes that compositional variability and potential toxicity under certain conditions remain important unresolved concerns. One systematic review also flagged that humic acid may worsen pulmonary emphysema, and a 2010 skin study found that the mineral fraction of humic-rich mud outperformed humic acid itself in suppressing inflammation, underscoring that the full picture is more complex than the largely supportive experimental literature alone might suggest.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Anti-ROS and NIR-II-Responsive Hyaluronic Acid Microneedle Loaded With Baical... Other 2024 Supports 100
Humic Acid Derived from Agricultural Biomass Mitigates Alveolar Bone Loss and... Other 2025 Supports 95
Effect of Humic Acid on Oxidative Stress and Neuroprotection in Traumatic Spi... Other 2021 Supports 90
Shilajit extract (ZhaXun) protects against acetaminophen-induced liver injury... Other 2026 Supports 85
In vitro determination of inhibitory effects by humic substances complexing Z... Other 2021 Neutral 85
Humic acid attenuates cisplatin-induced nephrotoxicity in rats. Other 2025 Supports 80
Humic Acid Derived from Vermicompost Inhibits Alveolar Bone Degradation and P... Other 2024 Supports 75
Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22. Other 2023 Supports 70
Water-retentive and anti-inflammatory properties of organic and inorganic sub... Other 2010 Mixed 65
Biomedical Applications of Humic Substances: From Natural Biopolymers to Ther... Review 2025 Supports 60
Natural products in the treatment of pulmonary emphysema: Therapeutic effects... Review 2022 55
The effect of combining humic and fulvic acids poultice on wound healing in m... Other 2024 Supports 50
Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD th... Other 2025 Supports 45
Waste to Wealth: Near-Infrared/pH Dual-Responsive Copper-Humic Acid Hydrogel ... Other 2023 Supports 40
Sorption, photodegradation, and chemical transformation of naproxen and ibupr... Other 2016 Neutral 35
The effect of topical 0.5% humic acid gel on male rats with skin ulcer. Other 2024 Supports 30

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