Graviola (Soursop) for Anti-Inflammatory

Research suggests that graviola (Annona muricata) may possess anti-inflammatory and antioxidant properties based on a small body of preclinical evidence, including a 2018 narrative review and several animal and cell-based studies. Studies indicate that leaf extracts have shown protective effects against gastric ulcers in rats, supported wound healing through antioxidant and putative anti-inflammatory mechanisms, and demonstrated cytotoxic activity against cancer cells in laboratory conditions, with the overall direction of findings being generally supportive but limited in scope. All available evidence comes from in vitro cell studies, rat models, and a review of preclinical literature, with no published human clinical trials or randomized controlled trials identified, which represents a significant limitation in drawing conclusions about effectiveness or safety in people. The 2018 review itself acknowledged that rigorous safety studies are still needed, and while the preclinical data are described as promising, they do not yet establish graviola as a proven anti-inflammatory intervention for human use.