Research suggests that Centella asiatica (Gotu Kola) has meaningful evidence supporting its role in skin health, particularly through its active triterpene compounds — asiaticoside, madecassoside, asiatic acid, and madecassic acid — which studies consistently indicate promote collagen synthesis, fibroblast proliferation, and wound healing across a range of conditions including burns, scars, stretch marks, and diabetic ulcers. The available evidence base consists primarily of reviews and systematic reviews, with a smaller number of clinical trials examining topical formulations, and the overall direction of findings is supportive, with studies also noting benefits for skin hydration, barrier function, photoprotection, and anti-inflammatory effects relevant to conditions like psoriasis and hypertrophic scars. Studies indicate that newer delivery technologies such as hydrogels and nanostructures may enhance the plant's effectiveness when applied topically, and at least one clinical trial supports its use in reducing scar outcomes while another demonstrates improvements in stretch marks through combination therapy. It is worth noting that the research landscape relies heavily on review-level evidence and in vitro or small clinical studies rather than large-scale randomized controlled trials, so while the general picture is consistently positive, higher-quality independent trials would strengthen the conclusions that can be drawn.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Centella asiatica in cosmetology. | Review | 2013 | Supports | 95 |
| Topical Application of Centella asiatica in Wound Healing: Recent Insights in... | Review | 2024 | Supports | 92 |
| Therapeutic properties and pharmacological activities of asiaticoside and mad... | Review | 2023 | Supports | 92 |
| Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and ... | Review | 2023 | Supports | 90 |
| Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and P... | Review | 2021 | Supports | 88 |
| Centella asiatica in dermatology: an overview. | Review | 2014 | Supports | 88 |
| A Systematic Review of the Effect of Centella asiatica on Wound Healing. | Systematic review | 2022 | Supports | 87 |
| Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. | Review | 2020 | Supports | 82 |
| Effectiveness of Fractional CO2 Laser and Topical Centella asiatica Combinati... | Other | 2024 | Supports | 80 |
| Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Contain... | Other | 2016 | Supports | 80 |
| The effect of Centella Asiatica cream on scar development in patients who und... | Other | 2023 | Supports | 78 |
| Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica... | Review | 2021 | Supports | 75 |
| Centella asiatica protects against UVB-induced HaCaT keratinocyte damage thro... | Other | 2012 | Supports | 75 |
| Madecassoside-functionalized platinum-based liposomes for sensitive skin: Enh... | Other | 2026 | Supports | 72 |
| Cosmeceuticals in photoaging: A review. | Systematic review | 2024 | Supports | 72 |
| Nutritional support for wound healing. | Review | 2003 | Supports | 70 |