Research suggests that Gotu Kola — particularly its standardized triterpenic fractions and key active compounds like asiaticoside and asiatic acid — may support blood circulation by reducing abnormal fluid leakage from capillaries, improving microvascular blood flow, and aiding the structural integrity of vein walls. The evidence base includes several randomized controlled trials and clinical studies that broadly support benefits in conditions such as chronic venous insufficiency, venous hypertension, and diabetic microangiopathy, with one pilot study also reporting improved healing of venous ulcers alongside measurable gains in skin microcirculation. Supporting reviews highlight multiple potential mechanisms — including anti-inflammatory, antioxidant, and collagen-regulating effects — that may work together to influence vascular health, and the compound has generally been reported as well tolerated across studies. However, limitations worth noting include relatively small sample sizes in available trials, some studies conducted in animal models, variability in the specific extracts and formulations tested, and the need for larger and longer-duration clinical investigations before firm conclusions can be drawn.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Preparation and evaluation of PEGylated asiatic acid nanostructured lipid car... | Other | 2020 | Neutral | 72 |
| A review of the microcirculation in skin in patients with chronic venous insu... | Review | 2006 | Supports | 67 |
| Increase water solubility of Centella asiatica extract by indigenous bioenhan... | Other | 2022 | Neutral | 62 |
| TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecu... | Review | 2011 | Supports | 57 |
| Total triterpenic fraction of Centella asiatica in chronic venous insufficien... | Review | 2001 | Supports | 52 |
| Improvement in venous ulcer closure and healing with Centellicum®. | Other | 2025 | Supports | 47 |
| In vivo disposition and metabolism of madecassoside, a major bioactive consti... | Other | 2013 | Neutral | 42 |
| Effects of Asiaticoside Treatment on the Survival of Random Skin Flaps in Rats. | Other | 2021 | Supports | 37 |
| Improvement of capillary permeability in patients with venous hypertension af... | Other | 1990 | Supports | 32 |
| Effects of the total triterpenic fraction of Centella asiatica in venous hype... | RCT | 2001 | Supports | 27 |
| Comparative study of the efficacy and tolerability of a unique topical scar p... | RCT | 2013 | Neutral | 22 |
| Evaluation of treatment of diabetic microangiopathy with total triterpenic fr... | RCT | 2001 | Supports | 17 |