Glycine for Anti-Inflammatory

Moderate evidence 30 studies

Research suggests that glycine demonstrates meaningful anti-inflammatory properties across multiple lines of preclinical evidence, with the most relevant studies indicating that glycine modulates the NF-κB signaling pathway, suppresses pro-inflammatory cytokine production, and activates glycine-gated chloride channels found on white blood cells including macrophages, neutrophils, and lymphocytes. Reviews from 1999, 2004, and 2023 consistently support these mechanisms, with animal model data showing protective effects against endotoxemia, organ injury, and immune overactivation, and the 2023 review further noting potential benefits for insulin response and metabolic inflammation. Studies also point to glycine-derived lipid molecules such as arachidonoyl glycine as playing a nuanced role in neuroinflammation, suggesting glycine's anti-inflammatory influence may extend beyond direct supplementation. However, the current body of evidence relies predominantly on in vitro studies, animal models, and narrative reviews rather than large-scale randomized controlled trials in humans, which means the clinical relevance and magnitude of these effects in people remain to be more firmly established.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Glycine: The Smallest Anti-Inflammatory Micronutrient. Review 2023 Supports 100
Nutraceutical treatment and prevention of benign prostatic hyperplasia and pr... Review 2019 Neutral 95
[Glycine]. Review 2004 Supports 90
Omega-3 Fatty Acid Derived Neuroactive Lipids - Docosahexaenoyl-Glycine and I... Other 2025 Supports 85
Targeted delivery of neural progenitor cell-derived extracellular vesicles fo... Other 2021 Neutral 85
Integrated metabolomic and genomic insights into amino acid incorporation wit... Other 2025 Neutral 80
Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Pre... Review 2022 Neutral 80
The electrophilic metabolite of kynurenine, kynurenine-CKA, targets C151 in K... Other 2025 Neutral 75
Glycine: a new anti-inflammatory immunonutrient. Review 1999 Supports 75
Epigenetic silencing of transposable elements by IRF2BP2 is a selective depen... Other 2025 Neutral 70
Glycine tabacina extract alleviates inflammatory bowel disease via NF-κB, JNK... Other 2025 70
Druggability of Phospholipase C-β Isoforms with Small Peptides Patterned afte... Other 2025 Neutral 65
Mycosporine-2-glycine exerts anti-inflammatory and antioxidant effects in lip... Other 2019 65
Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin... Other 2025 Neutral 60
Antipyretic and anti-inflammatory effects of inosine, an active component of ... Other 2024 Neutral 60
Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal c... Other 2025 Neutral 55
Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect a... Other 2021 Supports 55
Chemical genetics reveals <i>Leishmania</i> KKT2 and CRK9 kinase activity is ... Other 2025 Neutral 50
Mechanical Stimulation of Anti-Inflammatory and Antioxidant Hydrogels for Rap... Other 2024 50
Histone methyltransferase DOT1L differentially affects the development of den... Other 2025 Neutral 45
Synergistic Antioxidant and Anti-Inflammatory Effects of Phenolic Acid-Conjug... Other 2024 45
Intermolecular β-sheet formation guides the interaction between ubiquitin-lik... Other 2025 Neutral 40
Anti-Inflammatory Effect and Signaling Mechanism of Glycine max Hydrolyzed wi... Other 2023 40
Enhancing the iNKT cell immunotherapy platform by combining optimised CAR end... Other 2025 Neutral 35
Breed and Feeding System Impact the Bioactive Anti-Inflammatory Properties of... Other 2022 Neutral 35
From berries to brain: Assessing the impact of (poly)phenols in the MPTP mous... Other 2025 Neutral 30
Enhanced Anti-Inflammatory Efficacy Through Targeting to Macrophages: Synthes... Other 2017 30
Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESC... Other 2025 Neutral 25
WASp activity in macrophages prevents mechano-induced inflammation by protect... Other 2024 Neutral 20
Distinct immunity protein families mediate compartment-specific neutralisatio... Other 2025 Neutral 15

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Medical Disclaimer: Noyemi provides information from published research for educational purposes only. This content is not medical advice and does not replace consultation with a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any supplement regimen, especially if you take medications or have existing health conditions.