Fisetin is a naturally occurring flavonoid found in various fruits and vegetables, with strawberries being among the richest dietary sources. Research suggests that fisetin possesses notable antioxidant and anti-inflammatory properties, and it has attracted growing scientific interest for its potential role in cellular senescence, the process by which aging cells accumulate and contribute to age-related decline. Studies indicate that fisetin may support cognitive function by helping to maintain healthy neural pathways, with preclinical research showing promising effects on memory and learning in animal models. While much of the current evidence comes from laboratory and animal studies, early findings have generated considerable enthusiasm in the longevity research community, and human clinical trials are underway to better understand its effects on aging and overall health.
Compare this supplementResearch suggests that fisetin, a naturally occurring plant flavonoid, shows meaningful promise as an anti-aging comp...
View studies →Research suggests that fisetin possesses meaningful anti-inflammatory properties across a range of laboratory and ani...
View studies →Research suggests that fisetin, a naturally occurring plant flavonoid, may support cognitive function and offer neuro...
View studies →Research suggests a potential connection between the cellular stress pathways that fisetin is thought to target — inc...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 100 mg | Daily | cognitive function and neuroprotection in older adults | Dose used in pilot cognitive studies including work by Maher et al. |
| Capsule | 100–200 mg | Daily | general antioxidant support and cognitive function | Common in early human trials and commercial formulations |
| Capsule | 500 mg | Daily | inflammation and antioxidant support | Used in human supplementation studies examining bioavailability and inflammation markers |
| Capsule | 20 mg/kg | Daily for 2 consecutive days | senolytic dosing based on body weight for anti-aging research | Dose used in Aging Cell 2018 (Kirkland et al.) and related clinical pilot studies |
| Capsule | 1,000–1,500 mg | Twice daily for 2 consecutive days | senolytic protocol for anti-aging and cellular senescence clearance | Based on Mayo Clinic-led clinical trials (NCT02519959, NCT03475056) |