Sangre de Grado, commonly known as Dragon's Blood, is a deep red sap harvested from the Croton lechleri tree native to the Amazon basin, where it has a long history of traditional use for wound care and digestive complaints. Research suggests that the sap contains a rich profile of proanthocyanidins and the alkaloid taspine, which may contribute to its studied anti-inflammatory and antimicrobial properties. Studies indicate that one of its key compounds, crofelemer, has shown promise in supporting gut health and managing certain types of diarrhea by modulating chloride ion secretion in the intestinal lining. Preliminary research also points to potential benefits in wound healing, with some evidence suggesting the sap may help promote tissue repair and protect against infection, though further clinical studies are needed to fully understand its effects.
Compare this supplementResearch suggests that Sangre de Grado (Croton lechleri) may possess anti-inflammatory and immune-modulating properti...
View studies →Research suggests that Sangre de Grado (Croton lechleri) may possess antiviral and immune-modulating properties, with...
View studies →Research suggests that Sangre de Grado (Dragon's Blood), the red resin from South American Croton species, may suppor...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Extract | 100–500 mg | Daily | Anti-inflammatory, antimicrobial support | Range observed across preclinical and early-phase human studies |
| Extract | 125–250 mg | Four times daily | HIV-associated diarrhea, secretory diarrhea | Used in Phase II/III clinical trials with crofelemer extract |
| Liquid | 500 mg | Four times daily | Diarrhea management, traveler's diarrhea | Based on clinical trials using standardized SP-303 (Provir/Crofelemer) derived from Sangre de Grado |
| Liquid | 5–10 ml | Twice daily | Gut health, gastrointestinal inflammation | Traditional and ethnobotanical use; diluted resin taken orally |
| Topical | — | As needed | Wound healing, skin inflammation, insect bites | Traditional use; applied directly as latex resin to affected area |