Research suggests that Angelica sinensis, particularly its polysaccharide fraction (ASP), may support blood health through several complementary mechanisms, including reducing hepcidin levels to improve iron availability, suppressing inflammatory signaling pathways that interfere with red blood cell production, and stimulating erythropoietin in the context of kidney-related anemia. Studies indicate that in animal models, ASP has reversed markers of anemia of chronic disease, iron deficiency anemia, and chemotherapy-induced bone marrow suppression, while large retrospective database studies from Taiwan found that Angelica sinensis is among the most commonly prescribed herbs for anemia in clinical practice and was associated with improved survival in aplastic anemia patients using traditional Chinese herbal medicine alongside conventional care. However, the available evidence consists almost entirely of animal studies, cell culture experiments, database analyses, and observational studies rather than randomized controlled trials in humans, meaning that causal conclusions about efficacy and safety in people cannot yet be drawn. The existing research is broadly directionally supportive but preliminary, and authors across multiple studies consistently call for standardized clinical trials before these findings can be considered actionable for medical use.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Pharmacological action of Angelica sinensis polysaccharides: a review. | Review | 2024 | Mixed | 72 |
| The characteristics and prescription patterns of Chinese herbal medicine in c... | Other | 2018 | Supports | 67 |
| Polysaccharide from Angelica Sinensis Suppresses Inflammation and Reverses An... | Other | 2020 | Supports | 62 |
| Study on the synthesis of iron-based nanomedicine assisted by angelica sinens... | Other | 2024 | Supports | 57 |
| Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Relat... | Other | 2021 | Supports | 52 |
| Urine and plasma metabonomics coupled with UHPLC-QTOF/MS and multivariate dat... | Other | 2015 | Supports | 47 |
| Structural characterization of a polysaccharide from Qi-Gui herb pair and its... | Other | 2025 | Neutral | 42 |
| Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disea... | Other | 2017 | Supports | 37 |
| Correction of Anemia in Chronic Kidney Disease With Angelica sinensis Polysac... | Other | 2018 | Supports | 32 |
| Exploring the mechanism of Buxue Yimu Pill on hemorrhagic anemia through mole... | Other | 2021 | Supports | 27 |
| Angelica sinensis polysaccharides prevents marrow cell apoptosis during stres... | Other | 2026 | Supports | 22 |
| The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by po... | Other | 2014 | Supports | 17 |