Diindolylmethane, commonly known as DIM, is a compound naturally formed in the body during the digestion of indole-3-carbinol, found in cruciferous vegetables like broccoli, Brussels sprouts, and cauliflower. Research suggests that DIM may influence estrogen metabolism by promoting a more favorable balance of estrogen metabolites, which has drawn interest in areas such as hormonal balance, acne management, and prostate health. Studies indicate that DIM may support healthy metabolic pathways related to hormone processing, and early research has explored its potential antioxidant and cellular-protective properties. While often categorized alongside amino acid compounds in supplement contexts, DIM is technically a phytonutrient, and formulations like BioResponse DIM have been developed to enhance its bioavailability, as the compound can be difficult for the body to absorb on its own.
Compare this supplementResearch suggests that DIM may play a role in hormonal balance by influencing estrogen metabolism and aromatase activ...
View studies →Research suggesting a potential role for DIM in prostate health is currently limited to a single case report describi...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 100–200 mg | Daily | Acne treatment and hormonal acne in women | Based on clinical trials examining androgen-related acne reduction |
| Capsule | 2–4 mg | Daily | General health maintenance via dietary equivalence | Approximate DIM yield from cruciferous vegetable consumption in observational studies |
| Capsule | 108 mg | Daily | Hormonal balance and estrogen metabolism in women | Common in clinical trials using absorption-enhanced DIM formulations |
| Capsule | 150–300 mg | Daily | Metabolism support and body composition | Dosing range observed in studies on estrogen metabolism and weight-related outcomes |
| Capsule | 200–400 mg | Daily | Prostate health and androgen modulation in men | Used in RCTs for prostate cancer and BPH-related outcomes |