Research suggests that creatine supplementation is one of the more consistently supported ergogenic aids in the sports nutrition literature, with multiple reviews and position statements — including those from the International Society of Sports Nutrition — finding reliable improvements in high-intensity, short-duration exercise performance, maximal strength, power output, and fat-free mass gains, largely through enhanced intracellular creatine stores and improved ATP regeneration. Studies indicate these benefits extend across diverse populations, including adult men and women, adolescents, and older adults, with women and vegetarians potentially seeing amplified effects due to lower baseline creatine levels, and emerging evidence pointing to additional recovery benefits such as reduced muscle damage and faster restoration of force production between exercise bouts. The evidence is more mixed, however, when it comes to endurance-based exercise and situations where increased body mass may be a disadvantage, and the bulk of the strongest supporting evidence comes from reviews and narrative syntheses rather than a uniformly large body of independent randomized controlled trials on every specific use case. Several studies linked here examining related topics — such as cold water immersion, sodium bicarbonate, massage, and nanobubble water — do not directly investigate creatine but collectively illustrate the broader, competitive landscape of recovery and performance research within which creatine's evidence base remains comparatively robust.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| International Society of Sports Nutrition position stand: safety and efficacy... | Review | 2017 | Supports | 100 |
| Creatine for Exercise and Sports Performance, with Recovery Considerations fo... | Review | 2021 | Mixed | 95 |
| Creatine Supplementation in Women's Health: A Lifespan Perspective. | Review | 2021 | Supports | 90 |
| Ultra-small Particle Size Nanobubbles Water Drinking Exerts Antifatigue Effec... | Other | 2024 | Neutral | 85 |
| International Society of Sports Nutrition position stand: sodium bicarbonate ... | Review | 2021 | Neutral | 85 |
| Global skeletal muscle metabolomics reveals mechanisms behind higher response... | Other | 2025 | Neutral | 80 |
| Effects of cold water immersion after exercise on fatigue recovery and exerci... | Systematic review | 2023 | Neutral | 80 |
| Bat power-metabolic profiling of the Egyptian fruit bat <i>Rousettus aegypti... | Other | 2025 | Neutral | 75 |
| Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exerc... | Review | 2025 | Supports | 75 |
| Altered systemic bioenergetic reserve in chronic kidney disease predisposes h... | Other | 2024 | Neutral | 70 |
| Creatine Supplementation Beyond Athletics: Benefits of Different Types of Cre... | Review | 2024 | Supports | 70 |
| Exercise on cytokine responses in males and females: Effect of leucine, HMB a... | Other | 2023 | Neutral | 65 |
| The Effects of Massage Therapy on Sport and Exercise Performance: A Systemati... | Review | 2023 | Neutral | 65 |
| Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystroph... | Other | 2025 | Neutral | 60 |
| Creatine Supplementation in Children and Adolescents. | Review | 2021 | Supports | 60 |
| Shared genetic architecture links energy metabolism, behavior and starvation ... | Other | 2024 | Neutral | 55 |
| Effects of Creatine Supplementation on Athletic Performance in Soccer Players... | Meta-analysis | 2019 | Mixed | 55 |
| Relationships between acute race-induced changes in creatine kinase activity ... | Other | 2021 | Neutral | 50 |
| Timing of Creatine Supplementation around Exercise: A Real Concern? | Review | 2021 | Supports | 50 |
| A Ray of Light Against Age Related Neurodegeneration | Other | 2023 | Neutral | 45 |
| Creatine and Caffeine: Considerations for Concurrent Supplementation. | Review | 2015 | Mixed | 45 |
| Part II. Common questions and misconceptions about creatine supplementation: ... | Review | 2025 | Supports | 40 |
| Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse ... | Other | 2023 | Neutral | 40 |
| The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exerc... | RCT | 2024 | — | 35 |
| Metabolic snapshot of plasma samples reveals new pathways implicated in SARS-... | Other | 2021 | Neutral | 35 |
| Creatine in women's health: bridging the gap from menstruation through pregna... | Review | 2025 | Supports | 30 |