Calcium D-glucarate is a naturally occurring compound found in fruits and vegetables such as oranges, apples, and cruciferous vegetables, and it serves as a supplemental form of D-glucaric acid. Research suggests it may support the body's natural detoxification processes by inhibiting beta-glucuronidase, an enzyme that can interfere with the elimination of certain toxins and hormonal metabolites through a pathway known as glucuronidation. Studies indicate potential benefits for cholesterol management, with some animal research showing reductions in LDL cholesterol levels, while early laboratory and animal studies have explored its role in reducing the risk of certain cancers, though human clinical data remains limited. It has also drawn interest for its potential to support healthy estrogen metabolism, making it a popular choice among those focused on hormonal balance and overall metabolic wellness.
Compare this supplementThese are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 1,500–3,000 mg | Daily | Cancer risk reduction and detoxification support | Commonly referenced in clinical and preclinical research; used in breast cancer risk reduction studies |
| Capsule | 3,000–4,500 mg | Daily | Cancer risk reduction in high-risk populations | Higher dose range investigated in oncology-focused research protocols |
| Capsule | 200–400 mg | Three times daily | Cholesterol management and general detoxification | Doses used in early human trials examining glucuronidation and cholesterol metabolism |
| Capsule | 1,500 mg | Daily | Hormone metabolism and estrogen detoxification | Standard dose observed in studies examining beta-glucuronidase inhibition and estrogen clearance |