Research suggests that boron may play a role in supporting cognitive function and protecting against age-related cognitive decline, with a 2025 animal study finding that boric acid reduced oxidative stress markers and improved memory and learning in an accelerated aging rat model, and a 2024 review proposing potential neuroprotective relevance to Alzheimer's disease. The available evidence base consists primarily of narrative reviews and animal studies rather than controlled human trials, which substantially limits the conclusions that can be drawn. A 2008 systematic review found the evidence for boron and cognitive function to be conflicting, and several of the supporting studies are exploratory in nature, with authors consistently noting that the precise mechanisms by which boron might influence brain health remain poorly understood. Overall, while early findings are suggestive, rigorous human clinical trials are lacking, and the research at this stage does not yet establish a clear or well-characterized relationship between boron intake and cognitive outcomes in humans.
Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.
| Title | Type | Year | Direction | Match |
|---|---|---|---|---|
| Boron. | Review | 2008 | Mixed | 100 |
| Boron in Diet and Medicine: Mechanisms of Delivery and Detection. | Review | 2025 | Supports | 95 |
| Boron: An intriguing factor in retarding Alzheimer's progression. | Review | 2024 | Supports | 90 |
| Protective Effect of Boric Acid on Oxidative Damage and Cognitive Function in... | Other | 2025 | Supports | 85 |
| Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor int... | Other | 2023 | Neutral | 85 |
| N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2 | Other | 2021 | Neutral | 80 |
| Boron neutron capture therapy of brain tumors: functional and neuropathologic... | Other | 2000 | Neutral | 80 |
| Neurotoxicity Associated with Traumatic Brain Injury, Blast, Chemical, Heavy ... | Other | 2019 | Supports | 75 |