Bone Broth for Sleep Quality

Strong evidence 9 studies

Research suggests that glycine, an amino acid found in meaningful concentrations in bone broth, may support sleep quality through several proposed mechanisms, including lowering core body temperature and modulating inhibitory pathways in the nervous system. The available evidence consists primarily of narrative and systematic reviews synthesizing animal and human data, along with a small number of randomized controlled trials — most of which are limited by small sample sizes, short durations, and in some cases, multi-ingredient designs that make it difficult to isolate glycine's specific contribution. Studies indicate that glycine supplementation has been associated with reductions in nighttime awakenings, faster sleep onset, and modest improvements in next-day cognitive performance, though findings are not consistent across all measured outcomes, and several larger sleep parameters such as total sleep duration and sleep efficiency showed no significant differences from placebo in controlled trials. Overall, the direction of the literature is cautiously supportive, but researchers across multiple reviews consistently note that larger, more rigorously designed clinical trials are needed before confident conclusions can be drawn about glycine — and by extension, glycine-rich foods like bone broth — as a reliable tool for improving sleep.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
New therapeutic strategy for amino acid medicine: glycine improves the qualit... Review 2012 Supports 97
Collagen peptide supplementation before bedtime reduces sleep fragmentation a... RCT 2024 Supports 92
The effect of glycine administration on the characteristics of physiological ... Systematic review 2024 Supports 85
An Update of the Promise of Glycine Supplementation for Enhancing Physical Pe... Review 2024 Supports 82
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Review 2017 Supports 80
Nutritional modulators of sleep: A narrative review of vitamins, minerals, am... Review 2026 Supports 78
Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review. Review 2026 Supports 72
Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomiz... RCT 2023 Supports 70
Dietary glycine improves urine storage symptoms in urology outpatients. RCT 2021 Supports 62

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