Bacillus subtilis is a spore-forming probiotic bacterium that has drawn considerable research interest due to its remarkable resilience in the gastrointestinal tract, as its spore form allows it to survive stomach acid and reach the intestines intact. Studies indicate that Bacillus subtilis may support gut health by promoting a balanced intestinal microbiome, producing antimicrobial compounds that help manage less desirable bacteria, and contributing to the integrity of the gut lining. Research also suggests it may play a role in modulating immune responses, with some studies observing enhanced activity of certain immune cells following supplementation. While the body of evidence continues to grow, Bacillus subtilis remains one of the more widely studied spore-forming probiotics in both human and animal research.
Compare this supplementResearch suggests that Bacillus subtilis, in various forms including live bacteria and hardy spores, may support gut ...
View studies →Research suggests that Bacillus subtilis may support immune function across a range of animal models, with studies co...
View studies →Research suggests that Bacillus subtilis produces a range of biologically active compounds — including lipopeptides, ...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 99,999,999.99 CFU | Daily | antibiotic-associated diarrhea prevention | Based on clinical trials using spore-forming probiotic blends including B. subtilis |
| Capsule | 99,999,999.99 CFU | Daily | Diarrhea prevention and bowel regularity | Based on RCTs using Bacillus subtilis as a spore-forming probiotic for GI outcomes |
| Capsule | 99,999,999.99 CFU | Daily | gut health and digestive support | Common in clinical trials evaluating probiotic effects on gut microbiota |
| Capsule | 99,999,999.99 CFU | Daily | Gut health and digestive support | Common in clinical trials examining probiotic effects on gut microbiota |
| Capsule | 99,999,999.99 CFU | Daily | immune function support | Based on RCTs examining immune modulation with Bacillus subtilis DE111 |
| Capsule | 99,999,999.99 CFU | Daily | Immune function support | Based on RCTs evaluating immune modulation with Bacillus subtilis DE111 |
| Powder | 99,999,999.99 CFU | Daily | antimicrobial properties and pathogen reduction | Used in clinical and animal studies assessing colonization resistance |
| Powder | 99,999,999.99 CFU | Daily | Antimicrobial properties and pathogen suppression in gut | Common in clinical trials studying competitive exclusion of pathogens |