Bacillus clausii is a spore-forming probiotic bacterium, perhaps best known through the widely available product Enterogermina, and has been the subject of clinical research spanning several decades. Studies indicate that its spore-based nature allows it to survive stomach acid and reach the intestines intact, where it may help restore microbial balance, particularly during and after antibiotic use. Research suggests that Bacillus clausii may support the management of acute diarrhea in both children and adults, and emerging evidence points to potential benefits for upper respiratory tract health and broader immune function. Its resilience and stability at room temperature have made it one of the more extensively studied spore-based probiotics, though ongoing research continues to clarify the full scope of its benefits across different populations.
Compare this supplementResearch suggests that Bacillus clausii may support gut health, particularly in contexts where the microbiome has bee...
View studies →Research suggests that Bacillus clausii may support immune function in the context of intestinal infection, though th...
View studies →Research suggests a possible indirect connection between gut bacteria and respiratory immune responses, including tho...
View studies →These are commonly referenced dosage ranges for this supplement. They are not medical recommendations. Always consult a healthcare provider before supplementing.
| Form | Dose range | Frequency | Studied for | Source |
|---|---|---|---|---|
| Capsule | 99,999,999.99 CFU | Twice daily | general gut health and microbiome restoration | Common in clinical research using encapsulated spore formulations |
| Liquid | 99,999,999.99 CFU | Twice daily | acute diarrhea management in children and adults | Common in clinical trials using standard ampule formulation (2×10⁹ spores per dose) |
| Liquid | 99,999,999.99 CFU | Three times daily | antibiotic-associated diarrhea prevention and gut health support | Used in RCTs studying adjunct probiotic therapy with antibiotics |
| Liquid | 99,999,999.99 CFU | Daily | immune function and respiratory health in pediatric populations | Based on clinical trials in children with recurrent respiratory tract infections |