Agaricus Blazei for Anti-Inflammatory

Moderate evidence 15 studies

Research suggests that Agaricus blazei Murill demonstrates consistent anti-inflammatory properties across a range of preclinical studies, with laboratory and animal research showing that its bioactive compounds — particularly polysaccharides such as beta-glucans, as well as phenolics and other constituents — can reduce pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and markers such as NF-κB, COX-2, and myeloperoxidase, with proposed mechanisms including modulation of immune signaling pathways such as JAK-STAT and Akt. Studies indicate these effects have been observed across diverse experimental models, including animal models of osteoporosis, neuroinflammation, malaria, and UVB-induced skin damage, as well as cell-based assays involving mast cells and keratinocytes, lending breadth if not clinical depth to the overall picture. The body of evidence is composed almost entirely of in vitro and animal studies, along with several narrative and systematic reviews that consistently characterize the preclinical findings as promising; direct human clinical trial data specifically addressing anti-inflammatory outcomes remains sparse, and reviewers across multiple publications have noted that preparations are often unstandardized, mechanisms remain incompletely understood, and well-designed randomized controlled trials in humans are still needed before any firm conclusions about therapeutic efficacy can be drawn.

Related studies

Citations from PubMed and preprint sources. Match score (0-100) reflects automated search ranking, not clinical appraisal.

Title Type Year Direction Match
Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefi... Review 2017 Mixed 100
Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mush... Review 2020 Supports 95
Critical review on chemical compositions and health-promoting effects of mush... Review 2022 Mixed 90
Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, C... Other 2021 Neutral 85
Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone... Other 2012 Supports 80
Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damag... Other 2024 Supports 75
GC/MS and 2D NMR-based approach to evaluate the chemical profile of hydroalco... Other 2024 Supports 70
Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei... Other 2013 Supports 65
Agaricus blazei extract abrogates rotenone-induced dopamine depletion and mot... Other 2018 Supports 60
Anti-inflammatory activity of aqueous and alkaline extracts from mushrooms (A... Other 2009 Supports 55
Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Po... Review 2024 Supports 50
Does the Agaricus blazei Murill mushroom have properties that affect the immu... Review 2011 Supports 45
Effect of mushroom Agaricus blazei on immune response and development of expe... Other 2015 Supports 40
Polysaccharides and extracts from Agaricus brasiliensis Murill - A comprehens... Review 2021 Supports 35
A Systematic Review on Bioactivity of Brazilian Mushrooms (Agaricomycetes). Systematic review 2021 Supports 30

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